Dr. Davina C. M. Simoes' research focuses on understanding the molecular and cellular mechanisms that control skeletal muscle atrophy related to ageing and disease. The aim is to establish a foundation for interventions that can restore muscle homeostasis and prevent or reverse muscle atrophy in humans.
To achieve this, her team conducts detailed molecular and cellular analyses of skeletal muscle biopsies, integrating these findings with the clinical and functional characteristics of patients suffering from muscle wasting associated with lung cancer and with chronic obstructive pulmonary disease (COPD). They are particularly interested in the role of therapeutic pulmonary rehabilitation in muscle regeneration. Dr Simoes’ team has demonstrated that the differential expression of extracellular matrix (ECM) proteins is associated with muscle atrophy. Additionally, skeletal muscle samples from the MASS_Lifecourse study are being analysed to examine the morphological changes throughout the lifespan using a Lifecourse Approach, furthering the understanding of the selective vulnerability of type II muscle fibres as we age.
Additionally, Dr Simoes's team has developed complex in 3D-muscle engineered vitro models to investigate the signalling pathways within and between cells that contribute to muscle atrophy and impaired muscle homeostasis. They are also evaluating potential intervention strategies. These experimental models are continuously optimised by incorporating the latest technological advancements, such as SPACE technology, AI-based non-invasive image analysis, and organ-on-chip approaches, all while maintaining a strong focus on their translational potential.
Dr. Simoes has several academic responsibilities, including leading modules and lecturing to a large group of students in the biomedical and medical programs at 51. As a member of the EDI committee and the Women’s Network Steering Group, she actively supports and promotes gender equality in academia.
PhD August 01 1997
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